TABLE 2

Effect of intrarenal infusion of CBS and CGL inhibitors on renal hemodynamics and urinary excretory functions

PRG + AOAA (μmol/min/kg)
C
C
0.25
0.5
1.0
MAP (mm Hg) 114.75 ± 2.77 116.50 ± 1.35 113.63 ± 3.23 116.38 ± 1.16 115.00 ± 1.37
RBF (ml/min) 8.97 ± 0.36 8.93 ± 0.35 8.81 ± 0.39 8.53 ± 0.32 8.34 ± 0.37
GFR (ml/min/g kwt) 1.11 ± 0.05 1.09 ± 0.06 0.98 ± 0.05 0.75 ± 0.03* 0.50 ± 0.09*
U·V (μl/min/g kwt) 18.52 ± 0.58 19.15 ± 0.93 16.47 ± 0.31 12.70 ± 0.86* 11.72 ± 1.07*
UNa·V (μmol/min/g kwt) 2.42 ± 0.22 2.32 ± 0.13 1.94 ± 0.09 1.61 ± 0.06* 1.55 ± 0.12*
UK·V (μmol/min/g kwt) 1.80 ± 0.09 1.85 ± 0.13 1.51 ± 0.10 1.26 ± 0.07* 1.10 ± 0.07*
FF (%) 21.10 ± 0.53 19.93 ± 1.20 18.09 ± 1.31 14.71 ± 0.75* 11.81 ± 1.32*
FENa (%) 1.50 ± 0.30 1.47 ± 0.16 1.37 ± 0.13 1.48 ± 0.13 2.15 ± 0.09*
FEK (%)
32.39 ± 1.26
33.98 ± 1.58
30.94 ± 1.38
33.41 ± 1.60
44.06 ± 0.52*

  • ↵* P < 0.05 vs. control (C) by repeated measures ANOVA