TABLE 1

Apparent kinetic parameters of genistein and apigenin glucuronidation in different microsomes Data analyzed using simple Michaelis-Menten equation and nonlinear regression.

Flavonoid	Species	Duodenum Kinetic Parameter					Jejunum Kinetic Parameter					Liver Kinetic Parameter
Flavonoid	Species			K_m	V_max	CL_int	K_m	V_max	CL_int	K_m	V_max	CL_int
		μM	nmol / min / mg protein	ml / min / mg	μM	nmol / min / mg protein	ml / min / mg	μM	nmol / min / mg protein	ml / min / mg
Genistein	Wistar	2.5	8.1	3.2	4.5	3.4	0.76	11.1	3.1	0.28
	Gunn	4.6	7.3	1.6	2.4	4.1	1.8	15.3	3.8	0.25
Apigenin	Wistar	12.2	4.4	0.36	4.4	7.2	1.6	7.7	21.4	2.8
	Gunn	4.5	5.9	1.3	3.5	10.1	2.9	99.7	66.8	0.69
Prunetin	Wistar				0.48	4.3	8.9	0.51	0.56	0.91
	Gunn				0.81	2.2	2.7	0.77	0.19	0.25