TABLE 2

Effects of modafinil on transporter binding and uptake inhibition in rat brain Transporter binding and uptake assays were conducted as described under Materials and Methods. Each value represents mean ± S.D. for three separate experiments.

	Radioligand Binding Data					Uptake Inhibition Data
	DAT K_I	SERT K_i	NET K_i	DAT IC₅₀	SERT IC₅₀	NET IC₅₀
			nM
Modafinil	4800 ± 480	46,620 ± 8790	>92,000
GBR12909^a	12.0 ± 1.9	105 ± 11	497 ± 17
Cocaine^a	187 ± 19	172 ± 15	3210 ± 149
Modafinil				4043 ± 385	>50,000	136,000 ± 13,900
GBR12909^b				4.3 ± 0.3	73 ± 2	79 ± 5
Cocaine^b				487 ± 25	304 ± 10	779 ± 30

↵ a Binding data are reported in Rothman et al. (2008)
↵ b Uptake inhibition data are reported in Rothman et al. (2001)