TABLE 2

Slc genes that are significantly expressed in the BBB

Gene Symbol
Protein Name
Substrates
Relative BBB Expression Levela
Average Expression Factor in Brain
Slc 1a2 GLT-1 EAAT2 l-Glu, d-/l-Asp + 11.38
Slc2a1 GLUT1 Glucose, galactose, mannose, glucosamine +++ 0
Slc2a5 GLUT5 Fructose ++ 1
Slc2a10 GLUT10 Glucose, galactose + 1
Slc2a13 HMIT Myo-inositol + 8.9
Slc3a1 rBAT Slc7a9 heavy subunit + 7.43
Slc6a6 TAUT Taurine ++ 6.81
Slc6a20 SIT1 Imino acids +++ 4.33
Slc7a5 LAT1 Large neutral amino acids, T3, T4, l-dopa + 6.52
Slc7a11 xCT Cystine, l-glutamine +++ 0.57
Slc9a3r2 NHERF-2 NHE3 + 9.38
Slc11a2 DMT1 Fe2+, Cd2+, Co2+, Cu1+, Mn2+ + 3.67
Slc13a3 NaC2 SDCT2 Succinate, citrate, α-ketoglutarate ++ 0.1
Slc13a4 NaS2 Sulfate + 7
Slc13a5 NaC3 Citrate + 2.38
Slc14a1 UT-B1 Urea + 5.19
Slc15a2 PEPT2 Di- and tripeptides + 4.19
Slc15a3 PHT2 Histidine and di- and tripeptides + 2.67
Slc16a1 MCT1 Monocarboxylates + 6.10
Slc16a2 MCT8 T3, T4 + 7.9
Slc19a1 RFT N5-Methyltetrahydrofolate + 9.52
Slc19a2 ThTr1 Thiamine + 4.9
Slc20a2 PiT-2 Pi, Na+ + 8.57
Slco1a4 Oatp1a4 Digoxin, bile salts, organic anions, organic cations ++ 6
Slco1a6 Oatp1a6 Organic anions + 0
Slco1c1 Oatp1c1 T4, rT3, BSP + 6.81
Slc22a3 Oct3 Organic cations ++ 6.19
Slc22a5 OCTN2 l-Carnitine, organic cations ++ 6.19
Slc22a7 Oat2 Organic anions ++ 12.9
Slc22a8 Oat3 Organic anions ++ 5.67
Slc23a1 SVCT1 l-Ascorbic acid + 3.14
Slc23a2 SVCT2 l-Ascorbic acid + 10.05
Slc27a5 FATP5 Long-chain fatty acids + 5.38
Slc30a1 ZNT1 Zinc + 1.71
Slc38a3 SNAT4 Neutral amino acids + 8.9
Slc38a5
SNAT5
Neutral amino acids
+
4.29

  • +, significant expression; ++, strong expression; +++, very high expression.

  • ↵ a Relative expression level in the BBB.