URB597 reversal of compound 48/80-induced scratching URB597 (10 mg/kg) reverses scratching when given intravenously 10 min after administration of compound 48/80. All values are represented as mean ± S.E.M. (n = 7 mice/group).
Scratching | Behavioral Inactivity | ||||||
|---|---|---|---|---|---|---|---|
| Preinjection | Postinjection | Preinjection | Postinjection | ||||
| s | |||||||
| Vehicle | 38.6 ± 4.4 | 19.5 ± 4.1 | 4.5 ± 2.9 | 33.7 ± 10.2 | |||
| URB597 | 45.1 ± 7.2 | 4.7 ± 0.2** | 1.1 ± 0.8 | 47.0 ± 14.7 | |||
↵** P < 0.01 versus vehicle-treated postinjection group