TABLE 1

Maximal effect of scratching attenuation by nonsedating pruritus treatments

Drug Pretreatment
Vehicle Control
Control Scratching
Treatment Scratching
Scratching Reduction
Behavioral Locomotor Inactivity
Mean ± S.E.M. % p
2 mg/kg Dexamethasone Saline 279.7 ± 14.1 150.6 ± 16.0 46 0.40
10 mg/kg Loratadine Saline 299.0 ± 14.9 143.5 ± 15.4 52 0.33
10 mg/kg URB597a 1:1:18 256.7 ± 14.7 133.2 ± 8.5 48 0.96
30 mg/kg OL-135
1:1:18
264.5 ± 32.2
116.5 ± 17.1
56
0.27

  • ↵ a Data from four experiments with identical treatment conditions were combined