Evaluation of the potential of ibuprofen, celecoxib, and JNJ-20788560 to produce gastric mucosal lesions in fasted rats Shown are the mean ± S.E.M.
Treatment | Dose | n | Mean Lesion Score ± S.E.M. |
|---|---|---|---|
| Mg / kg p.o. | |||
| Vehicle | 5 ml/kg | 10 | 0 ± 0 |
| JNJ-20788560 | 10 | 10 | 0 ± 0 |
| JNJ-20788560 | 30 | 10 | 0 ± 0 |
| JNJ-20788560 | 100 | 10 | 0 ± 0 |
| Ibuprofen | 200 | 10 | 2.2 ± 0.6* |
| Celecoxib | 10 | 10 | 0.1 ± 0.1 |
| Celecoxib | 30 | 10 | 0 ± 0 |
| Celecoxib | 100 | 10 | 0 ± 0 |
| Celecoxib | 300 | 10 | 0.4 ± 0.2 |
↵* P < 0.05