Drug | n | One-Site Analysis | Global Fit Analysis | ||||
---|---|---|---|---|---|---|---|
nH | pKi ± S.E.M.a | H pKi ± S.E.M.a | L pKi ± S.E.M.a | ||||
Detrusor | |||||||
Darifenacin | 15 | 0.59 ± 0.04b | 7.14 ± 0.65c | 9.56 ± 0.72 | 6.94 ± 0.63 | ||
UK-148,993 | 5 | 0.71 ± 0.05b | 7.11 ± 0.65 | 9.20 ± 0.77 | 6.90 ± 0.64 | ||
Solifenacin | 5 | 0.78 ± 0.04b | 6.99 ± 0.63 | 8.201 ± 0.78 | 6.81 ± 0.65 | ||
Tolterodine | 5 | 0.99 ± 0.07 | 8.50 ± 0.61 | 9.46 ± 0.79 | 8.27 ± 0.65 | ||
Trospiumd | 11 | 0.78 ± 0.06 | 8.42 ± 0.64 | 8.37 ± 0.62 | |||
Fesoterodinee | 8 | 0.64 ± 0.04b | 8.36 ± 0.55c | N.D. | N.D. | ||
Mucosa | |||||||
Darifenacin | 9 | 0.57 ± 0.05b | 6.98 ± 0.67c | 8.84 ± 0.80 | 6.78 ± 0.64 | ||
UK-148,993 | 5 | 0.90 ± 0.08 | 6.99 ± 0.65c | 9.16 ± 0.84 | 6.83 ± 0.65 | ||
Solifenacin | 5 | 0.91 ± 0.07b | 6.90 ± 0.64 | 7.61 ± 0.87 | 6.78 ± 0.66 | ||
Tolterodine | 5 | 0.87 ± 0.10 | 8.39 ± 0.66 | 9.51 ± 0.83 | 8.23 ± 0.65 | ||
Trospiumd | 9 | 0.87 ± 0.04b | 8.54 ± 0.63 | 8.53 ± 0.63 | |||
Fesoterodinee | 6 | 0.53 ± 0.03b | 8.50 ± 0.55c | N.D. | N.D. |
↵ a Inhibition constant shown as mean pKi ± S.E.M.
↵ b The Hill slope (nH) was significantly different from unity (Student's t test, p < 0.05).
↵ c Two-site analysis was preferred.
↵ d The nonselective agent trospium was set to have same IC50 for both sites in the one tissue in the global fit analysis.
↵ e Fesoterodine was excluded from the global fit analysis.