TABLE 1

Physicochemical properties of the model compounds used

Compound
pKaa
Log D at pH 7.4a
Log D at 5.5a
Log D at 5.0a
Mol. Wt.
Propranolol 9.1basic 1.4 0.11 0.03 259
Ibuprofen 4.4acidic 0.8 2.6 3.0 206
Testosterone
N.A.b
3.5
3.5
3.5
288

  • ↵ a Values were calculated by the ACDLABS ACD/pKa/log D program (version 6.0).

  • ↵ b N.A., not available. Testosterone is a neutral compound.