Desensitization time constants for currents evoked by application of 124 μM ACh alone and in the combined presence of SB-206553 in α7-nAChR-GH4C1 cells
Time constants (average ± SEM) are presented for the fast and slow components together with their corresponding weights (Afast and Aslow). Slowing of desensitization in the presence of SB-206553 is more evident in the τslow component compared with the τfast. The τslow also exhibited a higher weight under all drug conditions examined. Five to 10 cells were tested in each condition.
τfast | Afast/Afast + Aslow) | τslow | Aslow/Afast + Aslow) | |
|---|---|---|---|---|
| ACh (124 μM) | 18 ± 10 | 0.23 ± 0.07 | 60 ± 6 | 0.82 ± 0.08 |
| SB-206553 (11 μM) | 23 ± 8 | 0.29 ± 0.09 | 64 ± 13 | 0.79 ± 0.08 |
| SB-206553 (33 μM) | 37 ± 14 | 0.27 ± 0.04 | 110 ± 19 | 0.73 ± 0.05 |
| SB-206553 (100 μM) | 37 ± 14 | 0.18 ± 0.02 | 229 ± 45 | 0.82 ± 0.06 |