Study | LPS | Treatment | Neutrophils | TNFα |
---|---|---|---|---|
% Total Cells | pg/ml | |||
Study 1 | No | Aerosolized vehicle | 4 ± 3 | 22 ± 7 |
Yes | Aerosolized vehicle | 64 ± 6 | 1836 ± 178 | |
Yes | Aerosolized TG100-115 (0.4% formulation) | 39 ± 5 | 952 ± 182 | |
Yes | Dexamethasone (0.3 mg/kg i.p.) | 22 ± 3 | 346 ± 68 | |
Study 2 | No | Aerosolized vehicle | 16 ± 4 | 256 ± 59 |
Yes | Aerosolized vehicle | 53 ± 4 | 1784 ± 240 | |
Yes | Aerosolized TG100-115 (0.004% formulation) | 18 ± 5 | 738 ± 227 | |
Yes | Aerosolized TG100-115 (0.04% formulation) | 36 ± 3 | 1077 ± 109 | |
| Yes | Aerosolized TG100-115 (0.4% formulation) | 33 ± 1 | 1267 ± 115 |