Study | Asthmatic | Treatment | Airway Resistance | Reduction |
---|---|---|---|---|
cm H2O/s/ml | % | |||
Study 1 | No | Aerosolized vehicle | 2.6 ± 0.3 | |
Yes | Aerosolized vehicle | 5.4 ± 0.8 | ||
Yes | Aerosolized TG100-115 (0.04% formulation) | 3.5 ± 0.3 | −68 | |
Yes | Aerosolized TG100-115 (0.4% formulation) | 4.0 ± 0.6 | −50 | |
Yes | Dexamethasone (3 mg/kg i.p.) | 3.0 ± 0.3 | −86 | |
Study 2 | No | Aerosolized vehicle | 1.8 ± 0.2 | |
Yes | Aerosolized vehicle | 6.3 ± 1.5 | ||
Yes | Aerosolized TG100-115 (0.004% formulation) | 4.3 ± 0.5 | −44 | |
| Yes | Aerosolized TG100-115 (0.04% formulation) | 4.0 ± 0.5 | −51 |