Population parameter estimates for the mechanism-based growth model
Group | Parameter (Unit) | Definition | Estimate | BSV |
|---|---|---|---|---|
| % | ||||
| Food intake | ||||
| WKY-N | Food(0) (kcal/day) | Food intake at start of study (3 weeks of age) | 29.4 | 20.7 |
| WKY-HF | Food(0) (kcal/day) | Food intake at start of study (3 weeks of age) | 34.5 | 20.7 |
| GK-N | Food(0) (kcal/day) | Food intake at start of study (3 weeks of age) | 24.6 | 20.7 |
| GK-HF | Food(0) (kcal/day) | Food intake at start of study (3 weeks of age) | 34.0 | 20.7 |
| WKY | Foodmax (g) | Maximal food intake | 171 | |
| GK | Foodmax (g) | Maximal food intake | 132 | |
| ALL | kout_Food (day-1) | Loss parameter for food | 0.0261 | 14.1 |
| ALL | CVFood (%) | Proportional error for food intake | 6.7 | |
| ALL | SDFood (kcal/day) | Additive error for food intake | 3.5 | |
| Body weight | ||||
| ALL | WT(0) (g) | Body weight at start of study | 52.3 | 16.6 |
| WKY-N | EF (g/kcal) | Efficiency to convert energy that is not needed for metabolism to body weight | 0.302 | 23.3 |
| WKY-HF | EF (g/kcal) | Efficiency to convert energy that is not needed for metabolism to body weight | 0.378 | 23.3 |
| GK-N | EF (g/kcal) | Efficiency to convert energy that is not needed for metabolism to body weight | 0.510 | 23.3 |
| GK-HF | EF (g/kcal) | Efficiency to convert energy that is not needed for metabolism to body weight | 0.393 | 23.3 |
| WKY-N | a · 20.65 (kcal/day/gLBM0.75) | Metabolic rate per LBM0.75 | 0.915 | 9.1 |
| WKY-HF | a · 20.65 (kcal/day/gLBM0.75) | Metabolic rate per LBM0.75 | 1.02 | 9.1 |
| GK | a · 20.65 (kcal/day/gLBM0.75) | Metabolic rate per LBM0.75 | 1.15 | 9.1 |
| ALL | CVWT (%) | Proportional error for body weight | 6.7 | |
| ALL | SDWT (g) | Additive error for body weight | 3.5 | |
| Abdominal fat | ||||
| WKY-N | AFatmax (g) | Maximal abdominal fat mass | 25.9 | |
| WKY-HF | AFatmax (g) | Maximal abdominal fat mass | 44.1 | |
| GK-N | AFatmax (g) | Maximal abdominal fat mass | 4.17 | 2.5 |
| GK-HF | AFatmax (g) | Maximal abdominal fat mass | 18.1 | 12.3 |
| WKY-N | IPFat (days) | Inflection point of abdominal fat growth curve | 79.1 | |
| WKY-HF | IPFat (days) | Inflection point of abdominal fat growth curve | 71.1 | |
| GK-N | IPFat (days) | Inflection point of abdominal fat growth curve | 27.2 | |
| GK-HF | IPFat (days) | Inflection point of abdominal fat growth curve | 22.9 | |
| ALL | CVAFAT (%) | Proportional error for abdominal fat | 36 | |
| ALL | SDAFAT (g) | Additive error for abdominal fat | ||
| Leptin | ||||
| ALL | kout_Lept (day-1) | Loss parameter for leptin | 4.22 | |
| WKY | kin1_Lept (ng/ml/day/g) | Leptin production from adipose tissue | 0.66 | 62.9 |
| GK | kin1_Lept (ng/ml/day/g) | Leptin production from adipose tissue | 3.03 | 62.9 |
| ALL | kin2_Lept (ng/ml/day/g) | Leptin production from lean body mass | 0.527 | 1.3 |
| ALL | I max | Maximal inhibition of food intake by leptin | 0.998 | 23.0 |
| WKY-N | IC50 (ng/ml) | Leptin concentration, which results in half-maximal inhibition of food intake | 67.7 | |
| WKY-HF | IC50 (ng/ml) | Leptin concentration, which results in half-maximal inhibition of food intake | 87.1 | |
| GK-N | IC50 (ng/ml) | Leptin concentration, which results in half-maximal inhibition of food intake | 186 | |
| GK-HF | IC50 (ng/ml) | Leptin concentration, which results in half-maximal inhibition of food intake | 234 | |
| ALL | CVLept (%) | Proportional error for leptin concentration | 31 | |
| ALL | SDLept (ng/ml) | Additive error for leptin concentration | 9.0 |
|
BSV, between-subject variability