Metabolism yields of IFO and C7,C9-diMe-IFO (TS121 and TS125) after human microsomes incubation for 1 h (n = 3) Because experiments do not reflect the initial reaction rates, data do not provide a quantitative measure of the relative formation rates of metabolites.
Compound | IFO, Human Microsomes | Compound Metabolite | TS121, Human Microsomes | TS125, Human Microsomes | |
|---|---|---|---|---|---|
| % | % | ||||
| N2-DCE-IFO | 0.5 | N2-DCP-Me-IFO | 0.8 | 1.6 | |
| N3-DCE-IFO | 1.3 | N3-DCP-Me-IFO | 0.3 | 1.2 | |
| 4-OH-IFO | 0.1 | 4-OH-diMe-IFO | 0.6 | 1.0 | |
| IFO (unchanged) | 98.1 | C7,C9-diMe-IFO (unchanged) | 98.3 | 96.2 | |