TABLE 1

Sedation and postural relaxation rating scales From Ko et al. (1999) and Butelman et al. (1999), based on Dykstra et al. (1987).

Score	Operational Description of Stimulus Required to Elicit a Behavioral Response^a
Sedation scale (home cage or chaired subjects)
0	No observable sedation, subject is alert to environment^b
1	Subject is attentive to ordinary movements of observer^c
2	Subject responds to loud noise in room (one hand clap)
3	Subject responds only to opening of cage latch (home cage studies) or knocking on chair (chaired studies)
4	Subject responds only to loud noise 3 feet away from its head
5	Subject responds only to touch
6	Subject does not respond to touch
Postural relaxation score (home cage only)
0	No observable facial or whole-body relaxation
1	Slight facial relaxation (including jaw slackening) or shoulder droop
2	Pronounced facial relaxation (including jaw slackening) or shoulder droop
3	Subject braces itself to sit up
4	Subject does not sit up

↵ a Stimuli are presented in sequential order, until a behavioral response (e.g., an orienting response) is elicited
↵ b Observer is stationary in room; lack of subject alertness is defined by apparent staring for >15 s
↵ c “Ordinary” movement by observer is walking within room