Effect of BFTZ on blood pressure, renal hemodynamics, and lithium clearance in vehicle and ZP120-treated rats Values for vehicle and ZP120 infused are mean of values for the third 30-min clearance period. Values for vehicle + BFTZ and ZP120 + BFTZ, respectively, are means of second 30-min clearance period with coadministration, where maximal response to BFTZ was seen. Mean values ± S.E.M. are presented. For ERPF, GFR, and CLi, n = 8. For MAP, n = 5.
Vehicle | Vehicle + BFTZ | ZP120 | ZP120 + BFTZ | |
|---|---|---|---|---|
| MAP (mm Hg) | 107 ± 4 | 112 ± 3 | 106 ± 3 | 111 ± 4 |
| ERPF (μ l/min/100 g BW) | 3517 ± 343 | 3432 ± 402 | 3193 ± 117 | 3307 ± 91 |
| GFR (μ l/min/100 g BW) | 1043 ± 102 | 975 ± 107 | 988 ± 39 | 959 ± 33 |
| CLi (μ l/min/100 g BW) | 315 ± 28 | 254 ± 30 | 285 ± 35 | 250 ± 20 |