Effects of saline (10 ml over 10 min i.v.), diltiazem (100 μg/kg over 2 min + 30 μg/kg/min × 8 min i.v.), serotonin (3 μg/kg/min × 10 min i.a.), CGRP(8-37) (30 μg/kg/min × 10 min i.v.), and CGRP(8-37) (30 μg/kg/min × 10 min i.a.) on HR, MAP, and ECG intervals (PR, QRS, and QTc) during sinus rhythm in the presence of an LAD stenosis Data are mean ± S.E.M. with n = 13 for saline and n = 6 for test agents.
Parameter/Protocol Time Point | Saline i.v. | Diltiazem i.v. | Serotonin i.a. | CGRP(8-37) i.v. | CGRP(8-37) i.a. |
|---|---|---|---|---|---|
| HR (bpm) | |||||
| Sinus + stenosis | 132.8 ± 3.4 | 136.2 ± 4.9 | 133.4 ± 6.0 | 136.0 ± 5.1 | 137.0 ± 6.0 |
| Sinus + stenosis treatment | 130.5 ± 3.7 | 141.3 ± 3.5 | 139.0 ± 4.3 | 131.2 ± 5.4 | 130.5 ± 6.8 |
| MAP (mm Hg) | |||||
| Sinus + stenosis | 102.4 ± 3.7 | 113.8 ± 7.8 | 94.1 ± 4.5 | 95.4 ± 5.2 | 105.5 ± 5.4 |
| Sinus + stenosis treatment | 100.3 ± 3.4 | 99.2 ± 10.3* | 82.3 ± 5.8† | 96.5 ± 4.8 | 106.7 ± 6.0 |
| PR (ms) | |||||
| Sinus + stenosis | 96.8 ± 3.4 | 91.9 ± 4.1 | 91.5 ± 5.3 | 97.2 ± 4.8 | 93.7 ± 3.7 |
| Sinus + stenosis treatment | 97.1 ± 3.2 | 101.6 ± 4.1† | 93.3 ± 5.0 | 96.4 ± 4.4 | 96.7 ± 4.9 |
| QRS (ms) | |||||
| Sinus + stenosis | 64.2 ± 4.6 | 52.7 ± 3.7 | 58.9 ± 4.7 | 60.6 ± 4.2 | 59.5 ± 6.4 |
| Sinus + stenosis treatment | 64.5 ± 4.5 | 52.6 ± 4.3 | 60.6 ± 4.3 | 61.0 ± 4.3 | 59.8 ± 5.8 |
| QTc (ms) | |||||
| Sinus + stenosis | 365.1 ± 9.1 | 382.3 ± 4.0 | 359.6 ± 8.1 | 383.8 ± 8.3 | 370.3 ± 10.4 |
| Sinus + stenosis treatment | 370.2 ± 9.2 | 383.9 ± 5.9 | 366.2 ± 8.3 | 384.2 ± 9.1 | 372.5 ± 11.6 |