Indices of whole-body glucose turnover in CH and HF diet-fed animals treated with either saline or CVT-3619 All data are reported as mean ± S.E. for the number of animals (n = 8) studied per treatment. MCRG and UG, along with MCRF and Uf are presented.
Diet | Treatment | MCRG | UG | MCRf | Uf |
|---|---|---|---|---|---|
| ml / min / 100 g | μmol / min / 100 g | ml / min / 100 g | μmol / min / 100 g | ||
| CH | Saline | 1.2 ± 0.2 | 10.7 ± 2.3 | 7.8 ± 1.7 | 2.2 ± 0.6 |
| CH | CVT-3619 | 1.3 ± 0.3 | 11.1 ± 2.5 | 8.9 ± 1.2 | 1.1 ± 0.4 |
| HF | Saline | 0.6 ± 0.1* | 5.8 ± 0.9* | 8.4 ± 1.3 | 2.3 ± 0.5 |
| HF | CVT-3619 | 0.8 ± 0.1 | 8.4 ± 1.1 | 7.6 ± 0.5 | 1.1 ± 0.1 |
↵* p < 0.05 between chow and high-fat feeding within a treatment as assessed by an ANOVA and a Tukey post hoc test