Key ISL parameters controlling disposition in normal and diseased livers
Parameter | Normal | Diseased | Description |
|---|---|---|---|
| MonteCarloRun | 48 | 48 | Simulation control |
| CycleLimit | 200 | 200 | |
| StepsPerCycle | 2 | 2 | |
| SSTypeRatio | 0.95 | 0.99 | Specification of direct (thicker, shorter) SS |
| DirSinCirc | 24 | 25 | |
| DirSinLenAlpha | 1.0 | 1.0 | |
| DirSinLenBeta | 0.085 | 0.085 | |
| DirSinLenShift | 3.0 | 3.0 | |
| TortSinCirc | 3 | 3 | Specification of tortuous (thinner, longer) SS |
| TortSinLenAlpha | 12.0 | 12.0 | |
| TortSinLenBeta | 0.075 | 0.075 | |
| TortSinLenShift | 0.0 | 0.0 | |
| A2BJumpProb * | 0.38 | 0.21 | Probabilistic compound movement |
| B2AJumpProb * | 0.37 | 0.30 | |
| B2CJumpProb * | 0.55 | 0.38 | |
| C2BJumpProb * | 0.478 | 0.55 | |
| CoreFlowRate | 2 | 2 | Flow control |
| SinusoidTurbo | 0.82 | 0.82 | |
| ECDensity | 0.65 | 0.65 | Cell density |
| HepDensity | 0.70 | 0.65 | |
| BinderPerCell * | 95 | 65 | Compound binding control |
| SoluteBindProb * | 0.5 | 0.35 | |
| SoluteBindCycles * | 11 | 28 | |
| MetabolizeProb * | 0.02 | 0.02 | Metabolism control |
|
ISL2WetLabScaling
*
| 1.0 | 1.0 | Compound resolution |
↵* In this study, this parameter is sensitive to PCPs of compound