The AUC0–15 min of CsA in the portal vein after intraloop administration to each portion of the small intestine in sham and I/R rats Results are mean ± S.D. of four rats. The AUC0–15 min value was estimated from the cumulative total of CsA during a 15-min test.
AUC0–15 min | Absorption Site of Small Intestine | ||||
|---|---|---|---|---|---|
| Upper | Middle | Lower | |||
| μg · min/ml | |||||
| Sham | 12.8 ± 1.4 | 5.3 ± 1.9 | 3.6 ± 1.2 | ||
| I/R | 7.1 ± 2.1** | 4.4 ± 1.9 | 2.4 ± 1.1 | ||
↵** p < 0.01 compared with sham rats