Plasma parameters in mice before chronic treatment and in basal or hyperinsulinemic conditions after a single or chronic intraperitoneally injection of CNTO736, Ex-4, or vehicle Values represent mean ± S.D. for at least eight mice per group.
Acute Study | Chronic Study | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Control | Ex-4 | CNTO736 | Control | Ex-4 | CNTO736 | |||||||||
| 0.1 mg/kg | 1.0 mg/kg | 0.1 mg/kg | 1.0 mg/kg | |||||||||||
| Body weight (g) | ||||||||||||||
| Start treatment | 26.7 ± 1.2 | 27.0 ± 1.9 | 26.6 ± 1.7 | 26.8 ± 1.4 | ||||||||||
| 12 weeks diet/after treatment | 30.9 ± 2.4 | 31.4 ± 0.9 | 31.3 ± 1.6 | 31.2 ± 2.2 | 27.3 ± 1.8 | 26.3 ± 2.0 | 26.1 ± 1.9 | 25.1 ± 1.3†† | ||||||
| Glucose (mM) | ||||||||||||||
| Start treatment | 6.5 ± 0.8 | 6.8 ± 0.8 | 6.7 ± 1.1 | 6.6 ± 1.4 | ||||||||||
| Basal | 6.3 ± 2.4 | 4.6 ± 1.1 | 5.5 ± 1.2 | 4.4 ± 1.0* | 6.0 ± 1.0 | 4.9 ± 1.1†† | 4.3 ± 1.0†† | 4.1 ± 0.8†† | ||||||
| Hyperinsulinemic | 7.3 ± 1.0 | 7.7 ± 0.9 | 7.3 ± 0.5 | 8.0 ± 0.8 | 6.9 ± 0.9 | 7.3 ± 0.9 | 7.6 ± 1.1 | 7.6 ± 0.9 | ||||||
| Free fatty acid (mM) | ||||||||||||||
| Start treatment | 0.9 ± 0.2 | 0.9 ± 0.2 | 1.0 ± 0.1 | 1.0 ± 0.2 | ||||||||||
| Basal | 1.3 ± 0.6 | 1.0 ± 0.2 | 1.1 ± 0.5 | 1.1 ± 0.5 | 1.1 ± 0.3 | 1.0 ± 0.3 | 1.1 ± 0.3 | 1.1 ± 0.2 | ||||||
| Hyperinsulinemic | 0.7 ± 0.3 | 0.5 ± 0.2* | 0.7 ± 0.3 | 0.6 ± 0.4 | 0.5 ± 0.2 | 0.4 ± 0.1 | 0.5 ± 0.1 | 0.4 ± 0.1 | ||||||
| Insulin (ng/ml) | ||||||||||||||
| Start treatment | 1.1 ± 0.4 | 1.0 ± 0.5 | 1.0 ± 0.5 | 1.1 ± 0.4 | ||||||||||
| Basal | 1.1 ± 0.8 | 0.7 ± 0.5 | 1.1 ± 0.8 | 0.9 ± 0.6 | 1.0 ± 0.7 | 1.4 ± 0.7 | 1.1 ± 0.6 | 1.4 ± 1.3 | ||||||
| Hyperinsulinemic | 3.1 ± 1.1 | 4.4 ± 0.8* | 3.5 ± 1.3 | 4.5 ± 1.7 | 5.4 ± 2.4 | 4.4 ± 0.9 | 4.6 ± 1.0 | 5.0 ± 1.9 | ||||||
| Glucagon (pg/ml) | ||||||||||||||
| Start treatment | 491 | 502 | 551 | 580 | ||||||||||
| Basal | 556 | 513 | 455 | 592 | 565 | 787 | 699 | 675 | ||||||
| Hyperinsulinemic | 569 | 509 | 476 | 670 | 575 | 631 | 580 | 632 | ||||||
| Glycerol (mM) | ||||||||||||||
| Start treatment | 0.2 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.0 | ||||||||||
| Basal | 0.2 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.0 | 0.2 ± 0.1 | 0.2 ± 0.0 | 0.2 ± 0.1 | ||||||
| Hyperinsulinemic | 0.1 ± 0.1 | 0.1 ± 0.0 | 0.1 ± 0.1 | 0.1 ± 0.1 | 0.2 ± 0.1 | 0.1 ± 0.1 | 0.1 ± 0.1 | 0.1 ± 0.1 | ||||||