MV | ICI | BP | TP | MP | |
---|---|---|---|---|---|
CTL | 100 ± 15 | 100 ± 15 | 100 ± 9 | 100 ± 12 | 100 ± 7 |
NS4591 0.1 μg/ml i.ves. | 105 ± 11 | 114 ± 11 | 93 ± 12 | 98 ± 8 | 97 ± 7 |
NS4591 1 μg/ml i.ves. | 120 ± 15 | 137 ± 16 | 82 ± 2 | 111 ± 9 | 77 ± 1 |
NS4591 10 μg/ml i.ves. | 124 ± 15* | 145 ± 15* | 94 ± 15 | 124 ± 14** | 68 ± 5* |
CTL | 100 ± 11 | 100 ± 9 | 100 ± 22 | 100 ± 12 | 100 ± 14 |
DC-EBIO 1 μg/ml i.ves. | 109 ± 8 | 119 ± 7 | 96 ± 10 | 106 ± 7 | 73 ± 6 |
DC-EBIO 10 μg/ml i.ves. | 129 ± 13** | 139 ± 8** | 104 ± 10 | 107 ± 7 | 66 ± 8* |
DC-EBIO 100 μg/ml i.ves. | 145 ± 14* | 145 ± 12* | 102 ± 15 | 118 ± 6 | 59 ± 12** |
CTL | 100 ± 13 | 100 ± 8 | 100 ± 7 | 100 ± 5 | 100 ± 5 |
NS4591 10 mg/kg p.o. | 108 ± 11 | 110 ± 11 | 89 ± 10 | 105 ± 7 | 92 ± 8 |
CTL | 100 ± 16 | 100 ± 14 | 100 ± 39 | 100 ± 9 | 100 ± 11 |
NS4591 30 mg/kg p.o. | 130 ± 10 | 134 ± 9 | 133 ± 35 | 126 ± 10** | 95 ± 13 |