Predicted additive ED50 values (Zadd) and experimentally determined ED50 values (Zmix) of mixtures of nalfurafine administered in combination with morphine in the antinociceptive assay in monkeys
Zadd (95% CL) | Zmix (95% CL) | |
|---|---|---|
| Nalfurafine + morphine | ||
| 0.0027:1, Nalfurafine/morphine | 0.76 (0.43–1.37) | 0.74 (0.43–1.29) |
| 0.008:1, Nalfurafine/morphine | 0.51 (0.29–0.92) | 0.34 (0.22–0.52) |
| 0.024:1, Nalfurafine/morphine | 0.26 (0.15–0.46) | 0.17 (0.11–0.26) |
CL, confidence limit