Sensitivity (EC50; nanomolar) and magnitude (Rmax, percentage) of vascular responses to ET-1 ACh and SNP in mesenteric arteries of control Wistar and diabetic GK rats with or without HF diet administration. Data are presented as mean ± S.E.M.
Control | Control HF | Diabetic | Diabetic HF | |
|---|---|---|---|---|
| ET-1 | ||||
| EC50 | 3.4 ± 1.5 | 1.9 ± 0.1 | 2.1 ± 0.7 | 3.5 ± 0.7 |
| Rmax | 55 ± 6 | 59 ± 5 | 58 ± 5 | 74 ± 5* |
| ACh | ||||
| EC50 | 8.1 ± 1.8 | 1.7 ± 1.5 | 6.0 ± 1.9 | 6.1 ± 1.9 |
| Rmax | 97 ± 3 | 96 ± 3 | 97 ± 2 | 74 ± 6* |
| SNP | ||||
| EC50 | 5.7 ± 2 | 3.5 ± 1.2 | 6.5 ± 2.3 | 23.5 ± 10.4* |
| Rmax | 102 ± 3 | 101 ± 2 | 99 ± 1 | 98 ± 2 |
↵* Interaction between disease (diabetes) and diet (high-fat diet) obtained by two-way ANOVA. p < 0.05; n = 5 to 8 per group