TABLE 4

Effects of desipramine (10 and 20 mg/kg i.p.) and fluoxetine (10 and 20 mg/kg i.p.) administered for 2 weeks after induction of colitis on serum TNF-α concentration in rats Values are expressed as mean ± S.E.M. (n = 8).


No.

Group

TNF-α ng/ml Serum
1 Normal 1.47 ± 0.021
2 Acetic acid control 13.92 ± 0.28*
3 10 mg/kg Desipramine 6.63 ± 0.16#
4 20 mg/kg Desipramine 3.73 ± 0.17#&
5 10 mg/kg Fluoxetine 9.32 ± 0.14#
6
20 mg/kg Fluoxetine
7.71 ± 0.18#
  • * P < 0.001 in comparison with group 1 normal control

  • # P < 0.001 in comparison with group 2 AAIC control

  • & P < 0.001 in comparison with groups 3, 5, and 6