Inhibition (pA2) of ET-1-induced contractions on isolated rat aortic rings without endothelium or S6c-induced contractions on isolated rat tracheal rings without epithelium in presence or in absence of endothelin receptor antagonist
pA2 | ETA/ETB Selectivity Ratio | |||
|---|---|---|---|---|
| Aorta (ETA) | Trachea (ETB) | |||
| Macitentan | 7.6 | 5.9 | 50/1 | |
| ACT-132577 | 6.7 | 5.5a | 16/1 | |
↵ a pKB