TABLE 1

IC50 concentrations of toxins to inhibit BK channel currents All values are means ± S.E.M., and n is number of cells.


BK Channel

Lolitrem B

Paxilline
hSlo 4.4 ± 0.3 nM (n = 19) 21.6 ± 1.2 nM (n = 12)
hSlo + β1 4.9 ± 0.3 nM (n = 8) 23.3 ± 5.0 nM (n = 8)
hSlo + β4
1.8 ± 0.1 nM (n = 8)
17.7 ± 2.8 nM (n = 8)