Experiment | Intact/Castrated | Treatment Time | E2 | T or DHT | Doses of Fispemifene and Tamoxifen | ||
---|---|---|---|---|---|---|---|
weeks | μg/day | ||||||
I | Antiestrogenicity study | Castrated | 3 | 5 | 3, 10, or 30 mg/kg Fispemifene | ||
II | Short-term anti-inflammatory study | Castrated | 3 | 70 | DHT (140) | 3, 10, or 30 mg/kg Fispemifene and 1 mg/kg tamoxifen | |
III | Establishment of inflammation in long-term studies | Intact | 13 | 83 | T (830) | ||
IV | Long-term anti-inflammatory study | Intact | 18 | 83 | T (830) | 30 mg/kg Fispemifene | |
V | The role of estrogen in the inflammation | Intact | 15 + 3 | 83 | T (830) |
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