EC50 values for α3/α6β2* and α4β2* nAChR-mediated [3H]DA release from medial and lateral caudate synaptosomes do not change with paraquat treatment EC50 and confidence interval (CI) values were derived from nonlinear regression analysis using GraphPad Prism. Data are from 6 to 8 animals.
EC50 (CI) | ||||
|---|---|---|---|---|
| Subtype | Region | Control | Paraquat | |
| μM | ||||
| α3/α6β2* | Medial | 0.94 (0.15–5.78) | 1.67 (0.26–10.8) | |
| Lateral | 1.38 (0.57–3.36) | 0.95 (0.30–3.01) | ||
| α4β2* | Medial | 0.89 (0.33–2.39) | 1.45 (0.50–4.19) | |
|
| Lateral | 0.92 (0.30–2.83) | 0.96 (0.24–3.90) | |