TABLE 1

Writhing behavior indicated as average number of writhes (±S.E.M.) during the observation period and average total duration of time spent writhing (±S.E.M.) in control, MD, and MW groups during the 1st and 20th episodes of withdrawal as a function of vehicle or acetic acid (0.32, 1.0, or 3.2%) injection

Percentage Acetic Acid
Control
MD
MW (1st episode)
MW (20th episode)
Number
Duration
Number
Duration
Number
Duration
Number
Duration
min min min min
Vehicle 1.7 ± 1.2 0.1 ± 0.1 0.0 ± 0.0 0.0 ± 0.0 0.6 ± 0.4 0.0 ± 0.0 2.2 ± 0.9 0.2 ± 0.0
0.32 1.5 ± 0.6 0.1 ± 0.1 Not done Not done 3.6 ± 1.6 0.2 ± 0.2 8.3 ± 2.4 0.7 ± 0.4
1 9.83 ± 5.3 0.9 ± 0.6 0.2 ± 0.2 0.0 ± 0.0 13.0 ± 4.7 9.5 ± 4.6 21.5 ± 5.4 11.5 ± 2.0
3.2
29.0 ± 3.8
15.5 ± 2.5
7.3 ± 3.5
2.8 ± 1.7
23.2 ± 3.0
22.4 ± 1.8
15.8 ± 1.7
25.1 ± 0.5