ED50 (95% CI) | Therapeutic Index | |||
---|---|---|---|---|
LMA | RR | |||
mg/kg | ||||
Rat MES | 1.5 (0.9–2.4) | 27 | >67 | |
Mouse MES | 8.6 (6.7–11.1) | |||
Rat PTZ | 2.2 (1.1–4.5) | 18 | >45 | |
Mouse 6 Hz (i.p.) | 10–25† | |||
Rat amygdala kindling | 3–9† | 4–13 | >11–33 | |
Rat locomotor activity | 40 (28–58) | |||
Rat Rotorod | >100 |
|
|
LMA, rat locomotor activity; RR, rat Rotorod
↵† ED50 not determined; numbers indicate active doses