Effect of ICA-27243 and carbamazepine on amygdala-kindled rats Data are submitted as mean ± S.E.M. or as the number of animals displaying a response compared with the number of animals tested.
Treatment | No. of Animals Responding to Initial Test Stimulus | ADD at Initial Test Stimulus (s)* | No. of Animals That Had an AD at Some Stimulus Intensity | % Increase in Current Intensity for First ADD Evoked | No. of Animals That Had Clonic Motor Seizure at Some Stimulus Intensity | Increase in Stimulus Intensity to Reach Clonic Motor Seizure* (%) | Current Intensity Required to Elicit Clonic Motor Seizure > 20 s (μA) | No. of Animals Displaying Rotorod Motor Impairment | |
|---|---|---|---|---|---|---|---|---|---|
| x ± S.E.M. | x ± S.E.M. | x ± S.E.M. | |||||||
| ICA-27243 | |||||||||
| Vehicle | 5/5 | 96 ± 19 | 5/5 | 0 | 5/5 | 0 | 146 ± 12 | 0/5 | |
| 1 mg/kg | 2/6 | 71 ± 34 | 6/6 | 11 ± 5 | 6/6 | 27 ± 5 | 215 ± 20 | 0/6 | |
| 3 mg/kg | 2/6 | 79 ± 6 | 6/6 | 21 ± 13 | 6/6 | 147 ± 102 | 400 ± 110‡ | 0/6 | |
| 9 mg/kg | 0/8† | 6/8 | 121 ± 57 | 2/8† | 674 ± 60**‡ | 1000**‡ | 0/8 | ||
| Carbamazepine | |||||||||
| Vehicle | 6/6 | 82 ± 11 | 6/6 | 0 | 6/6 | 0 | 175 ± 15 | 0/6 | |
| 20 mg/kg | 0/5† | 5/5 | 84 ± 8‡ | 5/5 | 80 ± 22 | 312 ± 65 | 2/5 | ||
| 30 mg/kg | 0/5† | 5/5 | 85 ± 19‡ | 5/5 | 110 ± 35 | 292 ± 75 | 5/5† | ||
| 40 mg/kg | 0/5† |
| 5/5 | 78 ± 26‡ | 5/5 | 166 ± 62$ | 450 ± 130 | 5/5† | |
↵† Significantly different from vehicle (Fisher's exact probability test; p ≤ 0.05)
↵‡ Significantly greater than vehicle (ANOVA followed by Dunnett's test; p ≤ 0.05)
↵* These data reflect the subset of animals that responded within each group; nonresponders are excluded
↵** These numbers represent data for the two of eight animals within the group that had a clonic motor seizure at the maximum stimulation of 1000 μA