TABLE 3

Effects of HD-205 on cocaine-induced locomotor activity after pretreatment with citalopram

Rats were surgically implanted with bilateral cannulae as described under Materials and Methods, and then after 7 to 10 days recovery, they were pretested for locomotor activity with 20 mg/kg i.p. cocaine (cocaine i.p. PRE column). After 2 days of baseline sessions, rats were injected i.p. with citalopram (7.5 mg/kg), and then 20 min later they were injected intrastriatally with either 1 μl of DMSO (n = 5) or 1 nmol of HD-205 in 1 μl of DMSO (n = 6). Locomotor activity was tested directly after HD-205 treatment (direct column), after i.p injection of 20 mg/kg cocaine (cocaine post column), and after intrastriatal injection of 6 nmol of cocaine (cocaine intrastriatal column), as described in Table 2. Data are expressed as percentage of baseline activity, and they represent mean values ± S.E.M.