BBB choline transporter inhibition constants for bAPi analogs
The apparent inhibition constants (Ki) for choline and the bAPi analogs at the BBB choline transporter. Data represent the mean ± S.E.M. for three to six independent observations.
Substrate | Choline Transporter Ki |
|---|---|
| μM | |
| Choline (Km) | 40 ± 3 |
| bPiHxI (C6) | 324 ± 15 |
| bPiHpB (C7) | 60 ± 7 |
| bPiOI (C8) | 123 ± 17 |
| bPiNB (C9) | 430 ± 13 |
| bPiDI (C10) | 79 ± 13 |
| bPiUB (C11) | 164 ± 21 |
| bPiDDB (C12) | 5 ± 3 |