TABLE 3

Effect of C8 and C12 bAPi on field stimulation-evoked [3H]DA overflow from rat striatal slices

Slices were superfused with a range of concentrations (0.001–10 μM) of analog for 60 min followed by field stimulation (2 min; 1 Hz; 120 pulses) and superfusion continued for 30 min. Superfusion buffer contained nomifensine (10 μM) and pargyline (10 μM). Each slice was exposed to only one concentration of analog. Control represents the response to field stimulation in the absence of analog. Data are mean ± S.E.M. total [3H]DA overflow expressed as a percentage of tissue tritium. n = 11 to 12 rats/analog.

bAPi Analog
Control
0.001 μM
0.01 μM
0.1 μM
1 μM
10 μM
bPiOI (C8) 2.48 ± 0.26 1.87 ± 0.34 2.36 ± 0.34 1.23 ± 0.18* 2.45 ± 0.31 2.45 ± 0.48
bPiDDB (C12)
2.75 ± 0.24
2.02 ± 0.24
2.27 ± 0.36
1.72 ± 0.37
1.91 ± 0.37
2.12 ± 0.42

  • ↵* p < 0.05 different from control, Dunnett's post hoc t tests.