TABLE 3
Plasma and brain Aβ 1–40 ED
50
values in P-gp KO and WT mice
P-gp KO Mouse ED
50
WT Mouse ED
50
Plasma
Brain
B/P
Plasma
Brain
mg / kg
mg / kg
Compound A
30
50
2
50
>100
Compound B
0.4
1.5
4
0.4
>40
Compound C
0.6
30
50
0.6
>100