TABLE 2

Plasma concentrations of GW2580 in adjuvant arthritis rats on day 21 of dosing

n = 3 per group except for study 2 at 16 h were data from individual rats are shown.

Study No.a
Days Dosed
GW2580 b.i.d.
Conc. at 2 hb
Conc. at 16 h
mg/kg μM
1 0-21 7.5 0.8 ± 0.08 0.04 ± 0.02
1 0-21 37.5 5.5 ± 1.1 0.3 ± 0.1
2 0-21 75 15.4 ± 1.6 3.3, 3.1
4 14-21 10 2.4 ± 0.3 0.03 ± 0.01
4 14-21 50 10.1 ± 0.3 0.26 ± 0.06
5
14-21
100
19.8 ± 2.8
4.9 ± 1.2

  • Conc., concentration.

  • ↵ a Arthritis study numbers 1 to 5 are described in the legend to Fig. 2.

  • ↵ b Plasma taken various times after GW2580 dosing.