TABLE 1

Plasma concentrations of GW2580 in normal male rats on days 1 and 21 of dosing

Data represent mean ± S.E.M. from n = 3 per group.


Dose

Day 1a

Day 21
Conc. at 2 h
Conc. at 16 h
Conc. at 1 h
Conc. at 16 h
μM
7.5 mg/kg 0.97 ± 0.1 0.004 ± 0.001 1.5 ± 0.1 0.003 ± 0.001
37.5 mg/kg 6.0 ± 0.27 0.09 ± 0.05 4.8 ± 0.6 0.31 ± 0.13
75 mg/kg
11.1 ± 0.9
0.53 ± 0.20
7.3 ± 0.8
0.75 ± 0.18
  • Plasma was taken at various times after GW2580 dosing.

  • a Conc., concentration.