TABLE 3

Selected hematological parameters

Statistical significance (P < 0.05, ANOVA) in comparison with control (c) and deferiprone (d) group is given.

Parameter/Group
Beginning of the Study
Before the Fifth Administration
End of the Study
Leukocytes (× 109/l)
    Control 6.17 ± 0.50 6.92 ± 0.36 3.80 ± 0.18*
    L1 (50 mg/kg) 7.22 ± 0.69 6.70 ± 0.39 3.72 ± 0.19*
    DAU 6.39 ± 0.54 4.82 ± 0.41*c 2.75 ± 0.38*
    L1 10 (mg/kg) + DAU 5.31 ± 0.34 4.58 ± 0.85*cd 2.74 ± 0.49
    L1 50 (mg/kg) + DAU 6.00 ± 0.48 5.09 ± 0.78 3.63 ± 0.95*
Erythrocytes (× 1012/l)
    Control 6.13 ± 0.17 6.16 ± 0.06 6.16 ± 0.12
    L1 (50 mg/kg) 6.52 ± 0.11 6.35 ± 0.12* 6.04 ± 0.14*
    DAU 6.04 ± 0.19 4.26 ± 0.24*cd 4.02 ± 0.30*cd
    L1 (10 mg/kg) + DAU 6.12 ± 0.16 4.04 ± 0.24*cd 4.33 ± 0.15*cd
    L1 (50 mg/kg) + DAU 6.39 ± 0.24 3.74 ± 0.48*cd 4.06 ± 0.28*cd
Hemoglobin (g/l)
    Control 128.9 ± 3.1 132.3 ± 2.0 131.6 ± 2.5
    L1 (50 mg/kg) 138.7 ± 3.5 137.3 ± 3.9 131.3 ± 4.2
    DAU 133.4 ± 3.7 94.2 ± 4.9*cd 84.9 ± 6.7*cd
    L1 (10 mg/kg) + DAU 129.6 ± 3.5 86.8 ± 4.4*cd 93.6 ± 4.1*c
    L1 (50 mg/kg) + DAU 137.3 ± 3.9 82.3 ± 10.1*cd 87.2 ± 5.8*cd
Hematocrit
    Control 0.407 ± 0.009 0.429 ± 0.008 0.412 ± 0.013
    L1 (50 mg/kg) 0.417 ± 0.010 0.422 ± 0.008 0.413 ± 0.012
    DAU 0.425 ± 0.011 0.314 ± 0.015*cd 0.287 ± 0.020*cd
    L1 (10 mg/kg) + DAU 0.414 ± 0.010 0.289 ± 0.013*cd 0.306 ± 0.016*cd
    L1 (50 mg/kg) + DAU 0.425 ± 0.008 0.261 ± 0.029*cd 0.292 ± 0.015*cd
Trombocytes (× 109/l)
    Control 290.6 ± 26.8 287.8 ± 29.8 306.0 ± 49.7
    L1 (50 mg/kg) 201.0 ± 18.1 209.8 ± 18.3 210.8 ± 15.4
    DAU 249.6 ± 22.3 176.5 ± 21.3*c 124.8 ± 13.5*c
    L1 (10 mg/kg) + DAU 244.9 ± 30.7 114.9 ± 21.1*cd 166.0 ± 19.2c
    L1 (50 mg/kg) + DAU
234.3 ± 12.3
121.4 ± 28.4*c
175.6 ± 32.9c

  • ↵* Statistical significance (P < 0.05, paired t-test) in comparison with the initial values.