TABLE 4

Activity of MRLSD-064, MRLSD-726, MRLSD-438, and MRLSD-667 on glutamate-induced [³⁵S]GTPγS binding

Concentration-response curves were determined in the presence of 1 μM glutamate in rat brain membranes and mGluR2-containing membranes from stably transfected cells. For the hmGluR3-containing membranes from stably transfected cells, 10 nM glutamate was used. Results are expressed as mean EC₅₀ values (lower-upper S.D.) and mean efficacy (E_max) ± S.E.M., expressed relative to the maximal stimulation achieved by glutamate alone. Summary data are calculated from three individual experiments performed in triplicate.