TABLE 1
Activity of MRLSD-650 on glutamate-induced [35S]GTPγS binding
Concentration-response curves were determined in the presence of 1 μM glutamate in membranes prepared from rat brain or recombinant cells expressing hmGluR2, or 10 nM glutamate for the hmGluR3 preparation. Results are expressed as mean EC50 values (lower-upper S.D.) and mean efficacy (Emax) ± S.E.M., expressed relative to the maximal stimulation achieved by 1 mM glutamate alone. Summary data are calculated from three individual experiments performed in triplicate.