Parent Compound (PC) | Route | Plasma | Plasma | Brain | Brain | Brain-to-Plasma Ratio (PC) |
---|---|---|---|---|---|---|
μg/ml | μM | μg/g tissue | μM | |||
Vehicle | i.m. | N.D. | N.D. | N.D. | N.D. | N.D. |
Curc | gav | N.D. | N.D. | 0.519 ± 0.098a | 1.412 | N.D. |
Curc | i.p. | 0.127 ± 0.035aa | 0.345 | 0.739 ± 0.019b | 2.010 | 5.85 |
Curc | i.m. | 0.238 ± 0.048b | 0.647 | 1.162 ± 0.004c | 3.157 | 4.88 |
Vehicle | i.m. | N.D. | N.D. | N.D. | N.D. | N.D. |
TC | gav | N.D. | N.D. | 0.274 ± 0.015d | 0.736 | N.D. |
TC | i.p. | 0.847 ± 0.019c | 2.302 | 0.765 ± 0.023b | 2.056 | 0.90 |
TC | i.m. | 0.971 ± 0.092c | 2.639 | 2.234 ± 0.163e | 6.007 | 2.28 |
N.D., not detectable.
↵ a Different letters represent statistical differences of means from each other between treatments within route of administration or between routes within treatments; P < 0.05.