Nic311 pharmacokinetic parameters with and without concurrent nicotine infusion (3.2 mg/kg/day)
Group (n = 5/Group) | Cl | Vd,ss | α t1/2 | β t1/2 | AUC |
|---|---|---|---|---|---|
| ml/h/kg | ml/kg | h | days | mg · h/ml | |
| Nic311 | 0.65 ± 0.04 | 163 ± 21 | 7.7 ± 1.6 | 8.0 ± 1.0 | 46.3 ± 3 |
| Nic311 + nicotine | 0.50 ± 0.06 | 122 ± 12 | 5.6 ± 0.9 | 7.6 ± 1.0 | 61.4 ± 8 |
| p value | 0.012 | 0.022 | 0.022 | 0.676 | 0.012 |