TABLE 1

Kinetic parameters of Ab01 and Ab02 binding to NHP IL-13a


Ligand

ka

kd

KA

KD

Rmax b


1 / ms 1 / s 1 / M M RU χ2c
Ab01 3.61 × 105 5.05 × 10–6 7.15 × 1010 1.40 × 10–11 35.6 3.3
Ab02
1.15 × 107
1.06 × 10–3
1.09 × 1010
9.20 × 10–11
49
2.48
  • a Surface plasmon resonance analysis of human or cynomolgus monkey IL-13 binding to immobilized Ab01 or Ab02 was performed. Kinetic constants were derived from Langmuir model analysis

  • b Rmax, maximal signal

  • c χ2, measure of curve fit accuracy