TABLE 2

Baseline hemodynamic and electrophysiological parameters in various groups Values are mean ± S.E.M. from eight rabbits.


Compounds

Dose

n

Mean BP

HR

ECG
PR
QRS
QT
QTc
MAPD90
μg / kg / min mm Hg beats / min ms
Vehicle 0 8 65 ± 2 185 ± 10 80 ± 2 32 ± 2 157 ± 7 152 ± 5 129 ± 4
Prazosin 10 8 68 ± 3 174 ± 12 78 ± 3 35 ± 6 163 ± 4 153 ± 2 134 ± 5
Lidocaine 200 8 66 ± 1 180 ± 5 79 ± 2 39 ± 1 165 ± 4 157 ± 3 132 ± 3
Ranolazine 120 8 67 ± 2 184 ± 13 77 ± 2 32 ± 1 159 ± 5 152 ± 4 128 ± 4
240 8 69 ± 1 179 ± 6 77 ± 3 34 ± 1 161 ± 3 154 ± 3 130 ± 3

480
8
69 ± 2
186 ± 9
79 ± 3
36 ± 2
155 ± 7
150 ± 4
130 ± 5