TABLE 1

Effect of ranolazine and prazosin on hemodynamics and ECG intervals in rabbits Values are mean ± S.E.M. from five rabbits.


Compound

Dose

n


Hemodynamics

ECG

Mean BP
HR
PR
QRS
QT
QTc
μg / kg / min mm Hg beats / min ms
Vehicle 0 5 Pre- 69 ± 2 197 ± 14 78 ± 4 32 ± 2 148 ± 6 146 ± 4
Post- 68 ± 2 194 ± 12 77 ± 4 32 ± 2 149 ± 6 147 ± 5
Prazosin 0.5 5 Pre- 71 ± 1 194 ± 16 76 ± 4 33 ± 2 152 ± 5 147 ± 2
Post- 65 ± 1* 200 ± 17 75 ± 5 33 ± 2 152 ± 6 149 ± 3
5 5 Pre- 72 ± 2 176 ± 13 82 ± 3 34 ± 2 155 ± 5 147 ± 4
Post- 68 ± 2 179 ± 12 80 ± 3 33 ± 2 150 ± 4 145 ± 3
Ranolazine 60 5 Pre- 74 ± 3 177 ± 19 74 ± 5 33 ± 2 151 ± 4 149 ± 4
Post- 69 ± 2 181 ± 18 72 ± 5 32 ± 2 151 ± 5 150 ± 4
480 5 Pre- 76 ± 4 186 ± 9 79 ± 2 32 ± 1 154 ± 7 148 ± 5



Post-
60 ± 4**
204 ± 10
77 ± 1
33 ± 1
166 ± 9**
165 ± 7**
  • * p < 0.05 compared with predrug (two-way repeated ANOVA followed by Bonferroni's test

  • ** p < 0.01 compared with predrug (two-way repeated ANOVA followed by Bonferroni's test)