hSERT | I167L | A169D | F170I | I172M | S174M | |
---|---|---|---|---|---|---|
Amitriptyline | 10 ± 5 | 2 ± 1 | 20 ± 7 | 5 ± 3 | 400 ± 100*** | 200 ± 70 |
Amoxepine | 300 ± 30 | 500 ± 200 | 800 ± 400 | 200 ± 20 | 1200 ± 100 | 400 ± 40 |
Atomoxetine | 200 ± 100 | 70 ± 9 | 50 ± 30 | 200 ± 100 | 5500 ± 2000*** | 1100 ± 800 |
Citalopram | 10 ± 2 | 6 ± 3 | 30 ± 10 | 7 ± 2 | 4900 ± 2300*** | 20 ± 3 |
Clomipramine | 0.3 ± 0.1 | 1.0 ± 0.4 | 0.3 ± 0.1 | 0.2 ± 0.1 | 50 ± 20*** | 3 ± 0.8 |
Desipramine | 100 ± 7 | 40 ± 10 | 20 ± 9 | 90 ± 10 | 900 ± 300*** | 200 ± 50 |
Doxepin | 100 ± 40 | 500 ± 200 | 300 ± 200 | 200 ± 60 | 200 ± 20*** | 300 ± 70 |
Imipramine | 5 ± 0.3 | 3 ± 0.3 | 5 ± 1 | 3 ± 1 | 400 ± 50*** | 20 ± 1 |
Fluoxetine | 10 ± 3 | 10 ± 6 | 20 ± 7 | 20 ± 7 | 700 ± 200*** | 20 ± 5 |
Fluvoxamine | 10 ± 4 | 8 ± 3 | 5 ± 1 | 10 ± 7 | 60 ± 20*** | 90 ± 20 |
Maprotiline | 16,000 ± 4000 | 8400 ± 2000 | 29,000 ± 10,000 | 15,000 ± 4000 | 16,000 ± 9000 | 20,000 ± 8000 |
Nisoxetine | 200 ± 50 | 200 ± 60 | 70 ± 30 | 200 ± 100 | 23,000 ± 11,000*** | 400 ± 100 |
Nortriptyline | 70 ± 7 | 40 ± 7 | 40 ± 20 | 50 ± 20 | 900 ± 200*** | 300 ± 40 |
Norclomipramine | 20 ± 8 | 5 ± 1 | 20 ± 10 | 9 ± 1 | 600 ± 200*** | 60 ± 30 |
Protriptyline | 90 ± 4 | 1800 ± 1000 | 200 ± 50 | 200 ± 80 | 2500 ± 700* | 290 ± 90 |
Sertraline | 1 ± 0.3 | 2 ± 1.0 | 0.8 ± 0.3 | 3 ± 1 | 80 ± 30*** | 2 ± 0.2 |
Trimipramine | 400 ± 200 | 1600 ± 300 | 1800 ± 500 | 300 ± 100 | 6700 ± 1400*** | 600 ± 200 |
Venlafaxine | 40 ± 10 | 20 ± 7 | 10 ± 4 | 40 ± 2 | 19,000 ± 4000*** | 50 ± 20 |
Zimelidine | 100 ± 70 | 500 ± 300 | 600 ± 200 | 200 ± 30 | 9800 ± 2200*** | 400 ± 70 |
3-α -Bis | 5000 ± 2000 | 5000 ± 3000 | 10,000 ± 3000 | 6000 ± 2000 | 21,000 ± 9000 | 7000 ± 30 |