TABLE 1

Systolic blood pressure (millimeters of mercury) Per, perindopril; Ind, indapamide

12 Weeks
13 Weeks
14 Weeks
15 Weeks
WKY 150 ± 6 149 ± 1 150 ± 1 156 ± 6
WKY Isch 158 ± 4 162 ± 3 157 ± 3 156 ± 8
SHR 192 ± 3*** 198 ± 3*** 193 ± 2*** 202 ± 5***
SHR Isch 190 ± 5*** 193 ± 4*** 199 ± 6*** 210 ± 5***
SHR + Per 193 ± 7*** 151 ± 7††† 140 ± 6††† 130 ± 3**†††
SHR Isch + Per 196 ± 2*** 154 ± 7††† 137 ± 10††† 145 ± 9†††
SHR + Ind 202 ± 4*** 197 ± 4*** 199 ± 6*** 211 ± 5***
SHR Isch + Ind 204 ± 5*** 181 ± 9*** 202 ± 7*** 196 ± 5***
SHR + Per + Ind 196 ± 2*** 138 ± 3†††§ 138 ± 3††† 124 ± 9**†††
SHR Ishc + Per + Ind
199 ± 3***
137 ± 2†††§
125 ± 3**†††§
123 ± 8**†††

  • ↵** p < 0.01

  • ↵*** p < 0.001 versus WKY

  • ↵††† p < 0.001 versus SHR

  • ↵§ p < 005 versus SHR + Per