TABLE 1

ED50 values (milligrams per kilogram s.c.) of TP-10 and standard antipsychotic agents for inhibition of spontaneous (SLA), PCP-stimulated, or amphetamine-stimulated locomotion and CAR




TP-10 PDE10A

Haloperidol D2

Ziprasidone D2/5-HT2A

Risperidone D2/5-HT2A

Clozapine Atypical
SLA 1.4 0.07 0.71 1.06 1.63
PCP LA 0.69 0.13 0.20 0.15 1.80
CAR 1.1 0.04 0.52 0.13 5.03
AMPH LA
2.6
0.02
0.17
0.07
0.87