TABLE 1

Statistical analysis of the combined effects of SR141716 and mCPP on break point in mice trained to respond for Ensure under a progressive ratio schedule of reinforcement


SR/mCPP Ratio

ED25 Predicted Additive (Zadd) ± S.E.M.

ED25 Observed (Zmix) ± S.E.M.

t

T

Significant?

ED25 Observed, Actual Dose Pairs, SR ± S.E.M.:mCPP ± S.E.M.
1:1 1.24 ± 0.260 0.353 ± 0.068 3.28 2.29 Yes 0.311 ± 0.059:0.042 ± 0.009
2:1 1.64 ± 0.413 0.321 ± 0.120 3.06 2.29 Yes 0.302 ± 0.113:0.019 ± 0.007
3:1 1.79 ± 0.460 1.17 ± 0.320 1.11 2.36 No 1.12 ± 0.307:0.050 ± 0.013
1:2 0.965 ± 0.222 0.507 ± 0.025 2.06 2.20 No 0.401 ± 0.020:0.106 ± 0.005
1:3
0.798 ± 0.182
0.895 ± 0.345
-0.25
2.36
No
0.644 ± 0.248:0.251 ± 0.097